Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ ... - Nature
2012年4月15日 · Interferon-γ (IFN-γ) engenders strong antiproliferative responses, in part through activation of p53. However, the long-known IFN-γ–dependent upregulation of human Trp-tRNA synthetase (TrpRS),...
Unique roles of tryptophanyl-tRNA synthetase in immune control …
2019年1月7日 · Tryptophanyl tRNA synthetase (WRS) is an essential enzyme as it catalyzes the ligation of tryptophan to its cognate tRNA during translation. Interestingly, mammalian WRS has...
Tryptophanyl-tRNA synthetase mediates high-affinity tryptophan …
Tryptophanyl-tRNA synthetase (TrpRS) is also highly expressed in IFN-γ–treated cells and also has high affinity and selectivity for Trp. Here, we investigated the effects of human TrpRS expression on Trp uptake into IFN-γ–treated human THP-1 monocytes or HeLa cells.
Structure of human tryptophanyl-tRNA synthetase in complex with tRNA
2006年6月23日 · We report here the first crystal structure of human tryptophanyl-tRNA synthetase (hTrpRS) in complex with tRNA Trp and Trp which, together with biochemical data, reveals the molecular basis of a novel tRNA binding and recognition mechanism. hTrpRS recognizes the tRNA acceptor arm from the major groove; however, the 3′ end CCA of the tRNA ...
Trytophanyl-tRNA Synthetases - Madame Curie Bioscience …
TrpRS from B. stearothermophilus has proven to be an excellent model system for structural studies of conformational changes during the cycle of amino acid activation by class I aminoacyl-tRNA synthetases.
Tryptophanyl-tRNA synthetase crystal structure reveals an …
1995年1月1日 · Background: Tryptophanyl-tRNA synthetase (TrpRS) catalyzes activation of tryptophan by ATP and transfer to tRNA Trp, ensuring translation of the genetic code for tryptophan. Interest focuses on mechanisms for specific recognition of …
Short tRNA anticodon stem and mutant eRF1 allow stop codon
2023年1月11日 · It combines a shortening of the tRNA Trp anticodon stem (AS) with a specific alteration of the eukaryotic release factor 1 (eRF1), leading to robustness, which was highly likely to be a ...
Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target …
2021年4月26日 · Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme that catalyzes the ligation of tryptophan (Trp) to its cognate tRNAtrp during translation via aminoacylation. Interestingly, WRS also plays physiopathological roles in diseases including sepsis, cancer, and autoimmune and brain diseases and has potential as a pharmacological target and ...
Crystal Structure of Human Tryptophanyl-tRNA Synthetase …
Human tryptophanyl-tRNA synthetase (hTrpRS) produces a full-length and three N terminus-truncated forms through alternative splicing and proteolysis. The shortest fragment that contains the aminoacylation catalytic fragment (T2-hTrpRS) exhibits the most potent angiostatic activity.
RCSB PDB - 2DR2: Structure of human tryptophanyl-tRNA …
2006年6月5日 · We report here the first crystal structure of human tryptophanyl-tRNA synthetase (hTrpRS) in complex with tRNA (Trp) and Trp which, together with biochemical data, reveals the molecular basis of a novel tRNA binding and recognition mechanism. hTrpRS recognizes the tRNA acceptor arm from the major groove; however, the 3' end CCA of the tRNA makes...
- 某些结果已被删除