Switching from Repression to Activation: MicroRNAs Can Up ... - Science
2007年12月21日 · We show that human microRNA miR369-3 directs association of these proteins with the AREs to activate translation. Furthermore, we document that two well-studied microRNAs—Let-7 and the synthetic microRNA miRcxcr4—likewise induce translation up-regulation of target mRNAs on cell cycle arrest, yet they repress translation in proliferating cells.
The Functions of MicroRNAs: mRNA Decay and Translational Repression
2015年11月1日 · Plant miRNAs repress translation via various organelle-bound factors. Although the mechanism is unclear, in vitro studies suggest that AGO1–RISC can block translation initiation and ribosome movement.
Translational Repression and eIF4A2 Activity Are Critical for MicroRNA …
2013年4月5日 · MicroRNAs (miRNAs) control gene expression through both translational repression and degradation of target messenger RNAs (mRNAs). However, the interplay between these processes and the precise molecular mechanisms involved remain unclear. Here, we show that translational inhibition is the primary event required for mRNA degradation.
MicroRNAs and their targets: recognition, regulation and an
2012年3月13日 · In plants and animals, miRNAs usually repress target expression by inducing mRNA deadenylation and degradation or by inhibiting translation. Many factors, including target site context, RNA-binding...
MiRmap: comprehensive prediction of microRNA target repression ... - PubMed
MicroRNAs, or miRNAs, post-transcriptionally repress the expression of protein-coding genes. The human genome encodes over 1000 miRNA genes that collectively target the majority of messenger RNAs (mRNAs). Base pairing of the so-called miRNA 'seed' region with mRNAs identifies many thousands of putative targets.
Gene silencing by microRNAs: contributions of translational repression …
2011年1月18日 · Animal microRNAs were originally thought to repress target translation, with little or no influence on mRNA abundance, whereas the reverse was thought to be true in plants. Now, however, it is...
The mechanism of micro-RNA-mediated translation repression is ... - PNAS
2008年7月1日 · MicroRNA-mediated repression of gene expression appears to involve a number of posttranscriptional events. It has been shown that miRNA target mRNAs are subject to deadenylation and destabilization in addition to translational repression (5–7).
Target Repression Induced by Endogenous microRNAs: Large …
2014年8月20日 · Here we investigate the quantitative relationship between endogenous microRNA expression and repression for 32 mature microRNAs in Drosophila melanogaster S2 cells. In general, we find that more abundant microRNAs repress their targets to a greater degree.
Towards a molecular understanding of microRNA-mediated gene …
2015年6月16日 · MicroRNAs (miRNAs) silence gene expression by repressing translation and accelerating target mRNA degradation. The current consensus is that miRNAs inhibit cap-dependent translation at initiation,...
Accurate microRNA target prediction correlates with protein repression …
2009年9月18日 · MicroRNAs are small endogenously expressed non-coding RNA molecules that regulate target gene expression through translation repression or messenger RNA degradation. MicroRNA regulation is performed through pairing of the microRNA to sites in the messenger RNA of protein coding genes.