EGFR and Lung Cancer - American Lung Association
2024年9月26日 · A mutation in the gene that codes for the EGFR protein can make cells grow too much, which can cause cancer. There are different types of EGFR mutations. Two common …
EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired
2021年6月1日 · Along with driver mutations, EGFR drives metastasis in many ways. Paracrine loops comprising tumor and stromal cells enable EGFR to fuel invasion across tissue barriers, …
EGFR Mutation and Lung Cancer: What is it and how is it treated?
Learn more about the EGFR mutation, how to detect it, and what are your treatment options for EGFR-positive lung cancer.
The changing treatment landscape of EGFR-mutant non-small-cell lung cancer
4 天之前 · Timeline of the identification of key EGFR mutations driving non-small-cell lung cancer (NSCLC) and landmark approvals of EGFR tyrosine-kinase inhibitors (TKIs) for patients with …
EGFR mutations and lung cancer - PubMed
Given that more than 60% of non-small cell lung carcinomas (NSCLCs) express EGFR, EGFR has become an important therapeutic target for the treatment of these tumors. Inhibitors that …
Comprehensive mutational scanning of EGFR reveals TKI ... - Nature
2024年3月28日 · Here, we report a comprehensive mutational analysis of EGFR function. We perform saturation mutagenesis of EGFR and assess function of ~22,500 variants in a human …
Treatment strategies and outcomes for patients with EGFR ... - Lung Cancer
2022年3月25日 · Pre-existing concurrent RB1 and TP53 mutations may play a role in SCLC transformation in patients with EGFR-mutant lung cancer. TP53-mutations are present in …
Epidermal growth factor receptor mutations in lung cancer
Recent studies suggest that insertion mutations in exon 20 of the EGFR gene might render the receptor about 100-fold less sensitive to EGFR-TKIs compared with other sensitizing EGFR …
EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired …
2021年6月1日 · In addition to over-production of EGF and its family members in tumors, EGFR is similarly over-produced, and mutant hyper-active forms of EGFR are uniquely found in some …
EGFR Lung Cancer: Symptoms, Diagnosis, Treatment, Outlook - Healthline
2023年1月5日 · Errors in the EGFR gene cause abnormal cell growth and division. Learn about EGFR mutation lung cancer, and discover how the mutation affects treatment.