EGFR Gene - GeneCards | EGFR Protein | EGFR Antibody
Oct 1, 2024 · EGFR (Epidermal Growth Factor Receptor) is a Protein Coding gene. Diseases associated with EGFR include Inflammatory Skin And Bowel Disease, Neonatal, 2 and Lung Cancer. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Signaling by EGFR in Cancer.
Epidermal growth factor receptor - Wikipedia
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer. [6]
Biochemistry, Epidermal Growth Factor Receptor - StatPearls
Dec 3, 2023 · The epidermal growth factor receptor (EGFR) family is a subclass of receptor tyrosine kinase (RTK) proteins and consists of 4 members: EGFR (ErbB1, HER1), ErbB2 (HER2, neu in rodents), ErbB3 (HER3) and ErbB4 (HER4).
EGFR (human) | Gene Target - PubChem
The EGFR gene provides instructions for making a receptor protein called the epidermal growth factor receptor, which spans the cell membrane so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell.
EGFR epidermal growth factor receptor [ Homo sapiens (human) ]
Nov 14, 2024 · EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer.
Review on Epidermal Growth Factor Receptor (EGFR) Structure ... - PubMed
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its …
RCSB PDB - 5WB7: Crystal structure of the epidermal growth …
Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways. Using crystallography and other approaches, we show how the EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region.
(PDF) Review on Epidermal Growth Factor Receptor (EGFR) Structure …
Mar 3, 2020 · EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, we explore EGFR structure and its mutations,...
Gene: EGFR (ENSG00000146648) - Summary - Homo_sapiens
EGFR (HGNC Symbol) This gene contains MANE Select ENST00000275493, ENSP00000275493. This gene has proteins that correspond to the following UniProtKB identifiers: P00533. This Ensembl/Gencode gene contains transcript (s) for which we have selected identical RefSeq transcript (s).
Crystal Structure of the Complex of Human Epidermal Growth …
In this study, the crystal structure of a 2:2 complex of human EGF and the EGFR extracellular region has been determined at 3.3 Å resolution. EGFR domains I–III are arranged in a C shape, and EGF is docked between domains I and III.