Characterization of the EGFR interactome reveals associated protein ...
We affinity-purified EGFR with its interacting proteins by coprecipitation from lysates of A431 cells. A total of 183 proteins were repeatedly detected in high-resolution MS measurements. For 15 of these, direct interactions with EGFR were listed in the iRefIndex interaction database, including Grb2, shc-1, SOS1 and 2, STAT 1 and 3, AP2, UBS3B ...
Proximity extracellular protein-protein interaction analysis of EGFR ...
2023年12月14日 · Receptor proteins, such as epidermal growth factor receptor (EGFR), interact with other proteins in the extracellular region of the cell membrane to drive intracellular signalling. Therefore,...
Biochemistry, Epidermal Growth Factor Receptor
2023年12月3日 · The epidermal growth factor receptor (EGFR) family is a subclass of receptor tyrosine kinase (RTK) proteins and consists of 4 members: EGFR (ErbB1, HER1), ErbB2 (HER2, neu in rodents), ErbB3 (HER3) and ErbB4 (HER4).
Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein ...
2019年8月5日 · YAP (yes-associated protein) is the main mediator of the Hippo pathway and has been identified as promoting cancer progression, drug resistance, and metastasis in NSCLC. Here, we review recent studies that examined the correlation between the EGFR, YAP pathways, and PD-L1 and demonstrate the mechanism by which EGFR and YAP regulate PD-L1 ...
Constitutive and ligand-induced EGFR signalling triggers
2014年12月15日 · Regular EGFR protein levels are increased in cancer cells and the receptor then becomes constitutively active. However, downstream signals generated by constitutively activated EGFR are...
Epidermal growth factor receptor: mechanisms of activation …
2003年3月10日 · The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-α, and the neuregulins.
Profiling of subcellular EGFR interactome reveals hnRNP …
2020年4月22日 · In this study, we investigated the subcellular interactome of EGFR by using a spectral counting-based approach combined with liquid chromatography–tandem mass spectrometry to understand the...
Time-resolved proximity labeling of protein networks associated …
2022年6月14日 · We show that Trk-fused gene (TFG), a protein known to function at the endoplasmic reticulum exit sites, is enriched in the proximity proteome of EGFR in early/sorting endosomes and localized in these endosomes and demonstrate that TFG regulates endosomal sorting of EGFR.
Epidermal growth factor receptor: Structure-function …
2018年10月1日 · The Epidermal Growth Factor Receptor (EGFR) is a trans-membrane protein implicated in a wide range of developmental biology processes; [2], [3], [4] and human cancers including glioblastoma, non-small cell lung cancer (NSCLC), head and neck cancer and colorectal cancer [5], [6], [7], [8], [9], [10], [11], [12].
Epidermal growth factor receptor - Wikipedia
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.