Cryo-EM is providing macromolecular structures with up to atomic resolution at an … 展开

An ideal session at the microscope requires a dataset with a good concentration of intact particles embedded as a monolayer in thin ice; the particles are randomly oriented and eve… 展开

Sample carriers are historically circular EM grids of 3 mm in diameter that consist of at least two components: a mesh base and foil. The mesh base is made of metal to attain mechanica… 展开

The ability to deposit a suitable monolayer of macromolecules onto an EM grid still presents an enormous challenge. While success has frequently been achieved for the deposition o… 展开

Following sample deposition on a carrier, the sample must be vitrified and remain in a glass-like state to preserve its interior features, thereby paving the way for reconstructions … 展开