T lymphocyte recruitment to melanoma brain tumors depends on …
2024年10月4日 · By visualizing spatiotemporal dynamics of T cell recruitment to brain tumors, we uncovered sites of intraluminal T cell attachment and extravasation in distinct, intercellular …
Defining the role of the tumor vasculature in antitumor immunity …
2018年1月25日 · Research over the past decades has highlighted the crucial role played by tumor-associated blood and lymphatic vasculature in supporting immunoevasion and in …
The Role of the Tumor Vasculature in the Host Immune Response ...
2016年12月20日 · Trafficking of effector T cells to tumors is complex and tightly regulated. T cell migration, activation, and differentiation are intricately linked processes. Following activation …
T Cell Trafficking through Lymphatic Vessels - PMC
T cell migration within and between peripheral tissues and secondary lymphoid organs is essential for proper functioning of adaptive immunity. While active T cell migration within a tissue is fairly …
Targeting the tumour vasculature: from vessel destruction to …
2024年8月29日 · Instead of promoting angiogenesis, cancer cells become motile and migrate along normal blood vessels within the surrounding tissue of the organ. Some tumours also …
T cell egress via lymphatic vessels is tuned by antigen ... - Nature
2023年2月27日 · Here we show that tumor-associated lymphatic vessels control T cell exit from tumors via the chemokine CXCL12, and intratumoral antigen encounter tunes CXCR4 …
Motility Dynamics of T Cells in Tumor-Draining Lymph Nodes: A …
The activated cytotoxic T cells exit TDLNs and arrive at the target tumor via blood circulation, to damage the tumor cells expressing cognate antigens. However, the mechanisms by which …
Trafficking of T Cells into Tumors - Cancer Research
2014年12月14日 · This review summarizes recent advances in our understanding of T-cell migration in solid cancer and immunotherapy based on the adoptive transfer of natural or …
Lymphatic Migration of Immune Cells - Frontiers
Like αβ T cells, γδ T cells can migrate from the skin (23, 95, 109) and tumors via lymphatic vessels to dLNs and comprise a large proportion of the cells in bovine lymph . …
Migrating into the Tumor: a Roadmap for T Cells - ScienceDirect
2017年11月1日 · In this review, we discuss variables that influence T cell migration into the tumor microenvironment. Chemokines can attract T cells to the tumor site and tumor intrinsic …