Review on Epidermal Growth Factor Receptor (EGFR) Structure ... - PubMed
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its …
Biochemistry, Epidermal Growth Factor Receptor - StatPearls
2023年12月3日 · The epidermal growth factor receptor (EGFR) family is a subclass of receptor tyrosine kinase (RTK) proteins and consists of 4 members: EGFR (ErbB1, HER1), ErbB2 (HER2, neu in rodents), ErbB3 (HER3) and ErbB4 (HER4).
Structure and dynamics of the EGFR/HER2 heterodimer
2023年2月13日 · Here, we report the cryo-EM structures of the EGFR/HER2 ectodomain complex with two EGFR ligands — epidermal growth factor (EGF) and epiregulin (EREG) — at resolutions of 3.3 Å and 4.5 Å,...
Epidermal growth factor receptor - Wikipedia
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
Crystal Structure of the Complex of Human Epidermal Growth …
In this study, the crystal structure of a 2:2 complex of human EGF and the EGFR extracellular region has been determined at 3.3 Å resolution. EGFR domains I–III are arranged in a C shape, and EGF is docked between domains I and III.
Structure and Dynamics of the EGF Receptor as Revealed by …
In this review, we have brought together sources of structural information from different disciplines regarding the atomistic structure of EGFR in its different oligomer forms and the presence and absence of the ligand stimulus.
RCSB PDB - 5WB7: Crystal structure of the epidermal growth …
2017年6月28日 · Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways. Using crystallography and other approaches, we show how the EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region.
(PDF) Review on Epidermal Growth Factor Receptor (EGFR) Structure …
2020年3月3日 · EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, we explore EGFR structure and its mutations,...
Epidermal growth factor receptor: Structure-function informing …
2018年10月1日 · We describe the structure, function and targeting of the EGFR family, starting with the extracellular components, i.e. the ectodomains (ECD), proceeding to the transmembrane and juxtamembrane components, and finishing with the intracellular domains, including the tyrosine kinase and C-terminal domains.
Epidermal growth factor receptor: Structure-function informing …
2018年10月1日 · Research on the epidermal growth factor (EGF) family and the family of receptors (EGFR) has progressed rapidly in recent times. New crystal structures of the ectodomains with different ligands, the activation of the kinase domain through oligomerisation and the use of fluorescence techniques have re …