Atorvastatin | C33H35FN2O5 | CID 60823 - PubChem
Atorvastatin was first synthesized in 1985 by Dr. Bruce Roth and approved by the FDA in 1996. It is a pentasubstituted pyrrole formed by two contrasting moieties with an achiral heterocyclic core unit and a 3,5-dihydroxypentanoyl side chain identical to its parent compound.
Atorvastatin - Wikipedia
Atorvastatin synthesis during discovery chemistry. The key step of establishing stereocenters, using of a chiral ester auxiliary approach. The first synthesis of atorvastatin at Parke-Davis that occurred during drug discovery was racemic followed …
Atorvastatin Calcium Trihydrate | C66H74CaF2N4O13 - PubChem
Atorvastatin Calcium is the calcium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A reductase, the enzyme which catalyzes the conversion of HMG-CoA …
Atorvastatin(1-) | C33H34FN2O5- | CID 17589822 - PubChem
Atorvastatin Calcium is the calcium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A ( HMG-CoA ) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate , a key step in cholesterol synthesis.
Atorvastatin: Uses, Interactions, Mechanism of Action - DrugBank …
Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease.
Spatial structure of atorvastatin and its complex with model …
2018年9月5日 · Spatial structure of atorvastatin and its complex with model membrane in solution studied by NMR and theoretical calculations
Atorvastatin | C33H35FN2O5 - ChemSpider
ChemSpider record containing structure, synonyms, properties, vendors and database links for Atorvastatin, 134523-00-5
3D structure for Atorvastatin (DB01076) | DrugBank Online
Chemical Structure; For Drug Discovery. Use Case. Drug Discovery & Repurposing. Visit DrugBank.com for detailed drug and target data for your pharmaceutical research. Products. Data Library. Explore detailed drug information packages to support your research & drug discovery. ... Structure for Atorvastatin (DB01076)
Crystal structure of atorvastatin calcium trihydrate Form I (Lipitor ...
The most prominent feature of the crystal structure is a hydrophilic layer parallel to the ab-plane. The atorvastatin anions bond to each side of the hydrophilic layer, forming a triple layer.
Spatial structure of atorvastatin and its complex with model …
2018年9月5日 · Intermolecular complex of atorvastatin with DPC micelle was investigated by NMR and computational methods in current study. There is a hope that the results presented in this paper will help to understand specific pharmacological features of …