Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger ...
2018年6月13日 · Our results show that DENV-NS4A exploits the acyltransferase activity of AUP1 to trigger lipophagy, a process regulated by ubiquitylation. This mechanism appears to be a …
Intracellular lipid droplet accumulation occurs early following …
2021年7月14日 · Lipid droplets (LDs) are increasingly recognized as critical organelles in signalling events, transient protein sequestration and inter-organelle interactions. However, the …
Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger ...
2018年6月13日 · Zhang et al. describe the role of AUP1, a lipid droplet-associated host factor that is exploited during flavivirus infections. Viral non-structural proteins NS4A and NS4B interact …
Glycerophospholipid remodeling is critical for orthoflavivirus
2024年10月7日 · Flavivirus infection is tightly connected to host lipid metabolism. Here, we performed shotgun lipidomics of cells infected with neurotropic Zika, West Nile, and tick-borne …
Modulation of Lipid Droplet Metabolism—A Potential Target for ...
2017年11月27日 · Lipid droplets (LDs) are endoplasmic reticulum (ER)-related dynamic organelles that store and regulate fatty acids and neutral lipids. They play a central role in …
Viral subversion of selective autophagy is critical for biogenesis of ...
2023年5月10日 · We previously identified that virus-triggered lipophagy was critical for flaviviral assembly, and is driven by the lipid droplet associated protein Ancient ubiquitin protein 1 …
Lipid Droplets: Formation, Degradation, and Their Role in Cellular ...
2024年3月24日 · Lipid droplets (LDs) are cellular organelles derived from the endoplasmic reticulum (ER), serving as lipid storage sites crucial for maintaining cellular lipid homeostasis. …
Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger ...
2018年6月1日 · Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production. An exquisite fine-tuning of selective autophagy by flaviviruses that …
Multifaceted Nature of Lipid Droplets in Viral Interactions and ...
2023年7月21日 · The NDRG1-DGAT1/2 pathway has been found to play a critical role in the exacerbation of lipid droplets during rabies virus infection. In addition, pharmacological …
Hijacking of Lipid Droplets by Hepatitis C, Dengue and Zika …
2020年10月24日 · Flaviviridae members, including hepatitis C, dengue and Zika viruses, extensively manipulate host lipid metabolism, underlining the importance of lipid droplets (LDs) …