Line probe assays for detection of drug-resistant tuberculosis ...
2022年5月13日 · This document was developed to provide practical guidance on interpretation of the most commonly used first- and second-line line probe assays (LPAs). In this updated …
Line probe assays are a family of DNA strip-based tests that determine the drug resistance profile of a MTBC strain through the pattern of binding of amplicons (DNA amplification products) to …
GLI guide for the interpretation and reporting of line probe assays ...
This guide has been developed to provide practical information on the interpretation of the most commonly used first- and second-line line probe assays (LPA).
Line Probe Assay [LPA] | Knowledge Base - NTEP
Line Probe Assay (LPA) is a rapid molecular test available at centralised laboratories. The assay is based on Polymerase Chain Reaction (PCR) that can simultaneously detect Mycobacterium …
most commonly used first- and second-line line probe assays (LPAs) (i.e., GenoType MTBDRplus v2.0 and GenoType MTBDRsl 2.0 assays; Bruker-Hain). In this updated v manual, the …
Comparison of GeneXpert and line probe assay for detection of
2019年10月15日 · The line probe assay (LPA), based on strip technology was used to diagnose TB and detect RIF as well as Isoniazid (INH) resistance due to mutations in rpoβ, and both …
Utility of line probe assay in detecting drug resistance and the ...
2022年5月20日 · Line probe assay has high test performance in detecting resistance to anti-TB drugs in EPTB isolates. The MTBDR plus test was slightly less sensitive for the detection of …
Frontiers | Molecular Diagnosis of Drug-Resistant Tuberculosis; A ...
2019年4月15日 · Line probe assays (LPAs) are basically DNA–DNA hybridization assays that allow the simultaneous detection of different mutations by using multiple probes 2 (Makinen et …
The use of molecular line probe assay for the detection of …
2016年11月1日 · WHO recommends the use of LPA as a rapid diagnostic test for detection of rifampicin and isoniazid resistance. The WHO recommended commercially available tests …
3.2 Diagnostic testing for TB, HIV and drug-resistant TB
Line-probe assays were the first molecular tests recommended by the World Health Organization (WHO). They significantly reduce the time needed to diagnose multidrug-resistant and …