An ionizable lipid toolbox for RNA delivery - Nature
2021年12月13日 · Ionizable lipids are positively charged at acidic pH to condense RNAs into LNPs, but are neutral at physiological pH to minimize toxicity. They can be protonated in the …
Accelerating ionizable lipid discovery for mRNA delivery using …
2024年5月13日 · Here we describe an accelerated approach to discovering effective ionizable lipids for mRNA delivery that combines machine learning with advanced combinatorial …
Ionizable Lipid Nanoparticles for mRNA Delivery - Tang - 2023 ...
2023年7月13日 · In this review, we summarize the characteristics and applications of iLNPs in delivering mRNA. We focus on the recent iLNPs for mRNA delivery, and classify the ionizable …
Optimization of the activity and biodegradability of ionizable lipids ...
2 天之前 · Ionizable lipids largely determine the biocompatibility of lipid nanoparticles (LNPs) and the efficacy for mRNA delivery. Rational design and combinatorial synthesis have led to the …
Tetrahydropyrimidine Ionizable Lipids for Efficient mRNA Delivery
2024年10月11日 · In this study, we employed a facile, catalyst-free, and versatile one-pot multicomponent reaction (MCR) to develop a library of ionizable lipids featuring a …
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells …
2023年1月27日 · We show that intraperitoneal delivery of mRNA-LNPs induces robust protein expression in the pancreas for structurally distinct ionizable lipids. This strategy induced …
Ionizable Lipid with Supramolecular Chemistry Features for RNA …
2023年6月13日 · The ionizable lipid is arguably the most important component of the LNP as it makes up 30–50 mol% of the total lipids in the formulation, which facilitates RNA binding …
Iterative Design of Ionizable Lipids for Intramuscular mRNA Delivery
2023年1月18日 · Our findings add to the mechanistic understanding of ionizable lipids and demonstrate that hydrogen bonding, ionization behavior, and lipid-to-mRNA mass ratio are key …
Nanoparticles for mRNA Delivery Get an Edge via Chemically Evolved Lipids
1 天前 · “Compared with standard ionizable lipids, the lead A3-lipid improved the hepatic delivery of an mRNA-based genome editor and the intramuscular delivery of an mRNA vaccine against …
Ionizable Lipids from Click Reactions for Lipid Nanoparticle …
2024年4月8日 · Ionizable lipid-containing lipid nanoparticles (LNPs) are regarded as promising nonviral vectors for gene therapy delivery systems. Rationale design of the ionizable lipid …