The Sodium-Iodide Symporter NIS and Pendrin in Iodide …
Uptake of iodide into the thyrocytes is mediated by an intrinsic membrane glycoprotein, the sodium-iodide symporter (NIS), which actively cotransports two sodium cations per each …
Minireview: The sodium-iodide symporter NIS and pendrin in …
Uptake of iodide into the thyrocytes is mediated by an intrinsic membrane glycoprotein, the sodium-iodide symporter (NIS), which actively cotransports two sodium cations per each …
甲状腺激素合成基因与碘代谢和甲状腺疾病的相关性研究进展
甲状腺滤泡细胞通过位于基底膜的甲状腺钠碘转运体（NIS）和位于顶膜的氯碘转运体（Pendrin）协同作用，将胞外碘化物逆浓度梯度从血浆转运至甲状腺滤泡腔内。
Pendrin Is an Iodide-Specific Apical Porter Responsible for Iodide ...
2002年7月1日 · We show here, using COS-7 cells and Chinese hamster ovary cells transfected with expression vectors encoding sodium iodide symporter or human Pendred syndrome gene …
The Sodium/Iodide Symporter (NIS): Molecular Physiology and …
Active iodide (I −) transport in both the thyroid and some extrathyroidal tissues is mediated by the N a + /I − symporter (NIS). In the thyroid, NIS-mediated I − uptake plays a pivotal role in …
Iodide transport: implications for health and disease
2014年5月30日 · The perchlorate (ClO 4 −) discharge test is a functional test that uses ClO 4 − to inhibit NIS and radioactive iodine to diagnose partial or total organification defects. This test …
The Sodium Iodide Symporter (NIS): Regulation and …
Iodide taken up into the thyroid follicular cell by NIS, is released to the lumen via pendrin, oxidized by thyroid peroxidase (TPO) with hydrogen peroxide (H 2 O 2) produced mainly by dual …
Structural insights into the mechanism of the sodium/iodide
2022年12月14日 · The sodium/iodide symporter (NIS) is the essential plasma membrane protein that mediates active iodide (I −) transport into the thyroid gland, the first step in the...
Sodium/Iodide Symporter (NIS): Characterization, Regulation, and ...
2003年2月1日 · NIS has been transduced into various kinds of cancer cells to render them susceptible to destruction with radioiodide. Most dramatically, the discovery of endogenous …
TSH Regulates Pendrin Membrane Abundance and Enhances …
2011年11月22日 · We determined whether TSH regulates pendrin abundance at the plasma membrane and whether this influences iodide efflux. Results of immunoblot and …