A liver immune rheostat regulates CD8 T cell immunity in chronic HBV …
2024年7月5日 · In preclinical models of persistent infection with hepatotropic viruses such as HBV, dysfunctional virus-specific CXCR6 + CD8 T cells accumulated in the liver and, as a characteristic...
Immunobiology and pathogenesis of hepatitis B virus infection
2021年5月17日 · It has been long known that hepatitis B virus (HBV) infects only humans, chimpanzees and, to a lesser extent, tree shrews (Tupaia belangeri) and that the parenchymal cell of the liver (the...
Single-cell landscape of immune cells during the progression from HBV …
2023年12月5日 · We analyzed scRNA-seq data from 118,455 immune cells obtained from livers of six healthy individuals, four patients with HBV infection, five patients with HBV cirrhosis, and three patients with HBV-associated HCC.
Immune Response in Hepatitis B Virus Infection - PMC
Hepatitis B virus (HBV) can replicate within hepatocytes without causing direct cell damage. The host immune response is, therefore, not only essential to control the spread of virus infection, but it is also responsible for the inflammatory events causing liver pathologies.
Integrated Proteogenomic Characterization of HBV-Related ... - Cell …
2019年10月3日 · We performed the first proteogenomic characterization of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues from 159 patients. Integrated proteogenomic analyses revealed consistency and discordance among multi-omics, activation status of key signaling pathways, and liver-specific ...
Hepatitis B and D virus entry | Nature Reviews Microbiology
2024年11月21日 · Chronic infection of hepatitis B virus (HBV) is the leading cause of liver cirrhosis and hepatocellular carcinoma. It affects an estimated 250 million people worldwide, resulting in 1.1 million ...
Hepatitis B virus biology and life cycle - PubMed
Hepatitis B virus (HBV) specifically infects hepatocytes and causes severe liver diseases. The HBV life cycle is unique in that the genomic DNA (relaxed-circular partially double-stranded DNA: rcDNA) is converted to a molecular template DNA (covalently closed circular DNA: cccDNA) to amplify a viral …
Hepatitis B virus biology and life cycle - ScienceDirect
2020年10月1日 · Hepatitis B virus (HBV) specifically infects hepatocytes and causes severe liver diseases. The HBV life cycle is unique in that the genomic DNA (relaxed-circular partially double-stranded DNA: rcDNA) is converted to a molecular template DNA (covalently closed circular DNA: cccDNA) to amplify a viral RNA intermediate, which is then reverse ...
Hepatitis B virus: virology, molecular biology, life cycle and ...
2017年11月2日 · The burden of chronic infection due to hepatitis B virus (HBV) is currently estimated at around 250 million worldwide (WHO; fact-sheet no. 204, ), while deaths as a result of the chronic sequelae of the disease, such as cirrhosis, hepatocellular carcinoma (HCC) or liver failure, stand at 800,000 annually [2, 3].
Advances in HBV infection and replication systems in vitro
2021年5月29日 · This review summarizes representative HBV in vitro infection systems, including recombinant cell lines obtained by integrating the HBV genome into the liver cancer cell genome by genetic engineering techniques and sodium-taurocholate co-transporting polypeptide (NTCP) overexpressing hepatoma cell lines permissive for HBV infection established ...