Glutaminase - Wikipedia
Glutaminase (EC 3.5.1.2, glutaminase I, L-glutaminase, glutamine aminohydrolase) is an amidohydrolase enzyme that generates glutamate from glutamine. Glutaminase has tissue-specific isoenzymes. Glutaminase has an important role in glial cells. Glutaminase catalyzes the following reaction: Glutamine + H 2 O → glutamate + NH + 4
Glutaminase - an overview | ScienceDirect Topics
Glutaminase is a deaminating enzyme that converts glutamine to glutamate. Glutamate is further metabolised to alpha-ketoglutarate and channelled into the TCA cycle. However, targeting glutaminase using small-molecule inhibitors was not effective to significantly reduce carbon flow into the TCA cycle [ 32 ].
Glutaminase - an overview | ScienceDirect Topics
Glutaminase is the enzyme which hydrolyses glutamine, the main respiratory fuel of the intestine, to yield glutamate and ammonia. Glutaminase has a central role in intestinal metabolism: the products of the reaction catalyzed by glutaminase can be transaminated, catabolized to yield energy or used for the biosynthesis of pyrimidine nucleotides ...
Glutaminase 1 Is Essential for the Differentiation ...
Glutaminase is the enzyme that converts glutamine into glutamate, which serves as a key excitatory neurotransmitter and one of the energy providers for cellular metabolism. Previous studies have revealed that mice lacking glutaminase 1 (GLS1), the ...
Glutaminase - an overview | ScienceDirect Topics
Glutaminase (GLS) is a phosphate-dependent enzyme that converts glutamine into glutamate and ammonia. Two isozymes of glutaminase have been identified in mammalian cells: kidney-type glutaminase encoded by the GLS gene and liver-type glutaminase encoded by GLS2 gene. Each gene produces two different variants.
Glutamine: Metabolism and Immune Function, Supplementation ...
Several enzymes are involved in glutamine metabolism; the two main intracellular enzymes are glutamine synthetase (GS, EC 6.3.1.2) and phosphate-dependent glutaminase (GLS, EC 3.5.1.2).
Glutaminase: a multifaceted protein not only involved in ...
The protein glutaminase has been traditionally considered as a mitochondrial enzyme, playing a key role in the energy and nitrogen metabolism of mammalian cells. However, new experimental evidence in the last few years has challenged this simplified view.
Glutaminase-1 Stimulates the Proliferation, Migration, and ...
Glutaminase-1 (GLS1) is a mitochondrial enzyme found in endothelial cells (ECs) that metabolizes glutamine to glutamate and ammonia. Although glutaminolysis modulates the function of human umbilical vein ECs, it is not known whether these findings extend to human ECs beyond the fetal circulation.
Glutaminase: A Hot Spot For Regulation Of Cancer Cell ...
2010年12月9日 · Recently, we have found that this is achieved through a marked elevation of glutaminase activity in cancer cells. Here we further consider these findings and the possible mechanisms by which this important metabolic activity is regulated.
Glutaminases - PubMed
In this chapter, we present a critical account of essential works on brain glutaminase 80 years after its discovery. We will highlight the impact of recent findings and thoughts in the context of the glutamate/glutamine brain homeostasis.