CD4+ T cell memory | Nature Immunology
2023年5月8日 · Memory CD4 + T cells mount an anamnestic response to reinfections that is quicker and of a higher magnitude than primary responses and can contribute to protective …
Expanding roles for CD4 + T cells in immunity to viruses - Nature
2012年1月20日 · CD4 + T cells help antiviral CD8 + T cells in two main ways: they maximize CD8 + T cell population expansion during a primary immune response and also facilitate the …
T cells in health and disease | Signal Transduction and ... - Nature
2023年6月19日 · Upon antigen stimulation, naïve T cells differentiate into CD4+ helper and CD8+ cytotoxic effector and memory cells, mediating direct killing, diverse immune regulatory …
TNF-α+ CD4+ T cells dominate the SARS-CoV-2 specific T cell response …
2022年6月21日 · By providing insight into the shifting quality of the SARS-CoV-2-specific CD4 + T cell response following infection, how this is impacted by vaccination, and which features most …
Activation Pathways that Promote CD4 + T Cells to Break …
CD4 + T cell activation is a coordinated process that requires three distinct signals: Signal 1, which is mediated by antigen recognition on MHC-II molecules; ... which continue to favor and …
T cell responses: naïve to memory and everything in between
C: antigen-stimulated CD4 T cells collaborate with B cells to promote antibody production, class switching, and memory B cell formation. Both CD4 and CD8 T cells clonally expand and …
SARS-CoV-2 epitope–specific CD4+ memory T cell responses
2022年4月21日 · CD4 + “helper” T cells play a central role as they differentiate into T helper type 1 (T H 1) cells to stimulate phagocytes and cytotoxic CD8 + T cells and T follicular helper (T …
Clonal analysis of immunodominance and cross-reactivity of the CD4 T …
2021年5月18日 · Here, we demonstrate in COVID-19–recovered individuals a robust CD4 + T cell response to naturally processed severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
Functional SARS-CoV-2 cross-reactive CD4 + T cells established
2023年3月1日 · These data support our hypothesis that the T cell response against OC43 may impact the response against SARS-CoV-2 from childhood until late adulthood. ... Clonal …
CD4+ T cell activation distinguishes response to anti-PD-L1+anti …
2024年3月12日 · We conducted a window-of-opportunity study in head and neck squamous cell carcinoma (HNSCC) to examine the contribution of anti-CTLA4 to anti-PD-L1 therapy. Single …