Aiolos: a molecular guardian of type 2 innate immune cell
2021年8月18日 · Aiolos has been shown to play crucial roles in a wide variety of immune cells and responses by both directly promoting the transcription of specific genes, and indirectly silencing gene...
In this issue of Mucosal Immunology, two papers identify a role for the transcription factor Aiolos in the tissue-speci c localisation and function of eosinophils and type 2 fi innate lymphoid...
Aiolos regulates eosinophil migration into tissues - PMC
The loss of Aiolos impacted eosinophil gene expression involved in cellular pathways related to cell migration and intracellular signaling. Our finding parallels those by others demonstrating that Aiolos mediates its effect on chemotaxis by altering gene expression of chemokine receptor, integrin and tight junction genes 20,21,35. Indeed, the ...
The transcription factor Aiolos restrains the activation of intestinal ...
2023年12月4日 · In this Article, we found that Aiolos controlled the expression of genes encoding NK1.1 and other NK receptors, cytotoxic mediators and IFN-γ in uIELs, in part by attenuating IL-15 signaling.
Critical function of Ikaros in controlling Aiolos gene expression
2007年4月17日 · We present here the cloning and characterization of the human Aiolos promoter. We have delineated a positive regulatory region important for the promoter activity of the Aiolos gene. Within this positive regulatory region, NFκB, Ikaros and AP4-binding sites are critical for Aiolos promoter activity in vitro and in vivo.
Aiolos, a lymphoid restricted transcription factor that interacts …
1997年4月15日 · Aiolos was identified as a homolog of Ikaros whose expression is restricted to the lymphoid lineage. The Aiolos protein shows extensive homology to the largest Ikaros isoform, Ik‐1, throughout the DNA binding and C‐terminal domains.
Disease-associated AIOLOS variants lead to immune deficiency ...
2024年2月2日 · AIOLOS, also known as IKZF3, is a transcription factor that is highly expressed in the lymphoid lineage and is critical for lymphocyte differentiation and development. Here, we report on 9 individuals from 3 unrelated families carrying AIOLOS variants Q402* or E82K, which led to AIOLOS haploinsufficiency through different mechanisms of action.
Aiolos: An Ungrateful Member of the Ikaros Family - Cell Press
2007年3月23日 · Ikaros family members play an important role in hematopoietic development. show that pre-BCR signaling induces Aiolos expression, which in turn suppresses the expression of the pre-BCR component λ5 and eliminates the very structure that signaled its appearance.
Expression of Ikaros family transcription factor IKZF3 (Aiolos) increases during murine eosinophil lineage commitment and maturation. Herein, we investigated Aiolos expression and function in...
Aiolos: a molecular guardian of type 2 innate immune
2021年11月1日 · This study indicates that Ahr promotes Aiolos expression in ILC2s by promoting gene accessibility within Ikzf3 locus and that targeting Aiolos in ILC2s could pave the way for novel interventions to alleviate ILC2-mediated inflammation.