Stem cell aging: mechanisms, regulators and therapeutic …
Here we explore key molecular pathways that are commonly perturbed as tissues and stem cells age and degenerate. We further consider experimental evidence both supporting and refuting the notion that modulation of these pathways per se can reverse aging phenotypes.
Ageing and rejuvenation of tissue stem cells and their niches
2022年7月20日 · During ageing, stem cells decline in their regenerative potential and ability to give rise to differentiated cells in the tissue, which is associated with a deterioration of tissue integrity...
Effect of aging on stem cells - PMC - PubMed Central (PMC)
In this review, we will first focus on the various aging disease-related stem cell dysfunction and then address the several concepts on potential mechanisms that cause aging-related stem cell dysfunction. We will also discuss current strategies for …
Stem cell aging: mechanisms, regulators and therapeutic
Here we explore key molecular pathways that are commonly perturbed as tissues and stem cells age and degenerate. We further consider experimental evidence both supporting and refuting the notion that modulation of these pathways per se can reverse aging phenotypes.
Stem-Cell Aging and Pathways to Precancer Evolution
2023年10月4日 · We examine the pathophysiological changes associated with stem-cell aging and inflammation and the contribution of those processes to the development of cancer.
How stem cells age and why this makes us grow old
Recent data suggest that we age, in part, because our self-renewing stem cells grow old as a result of heritable intrinsic events, such as DNA damage, as well as extrinsic forces, such as...
When stem cells grow old: phenotypes and mechanisms of stem cell aging ...
In this Review, we discuss what is known about aging in some major stem cell populations: hematopoietic stem cells (HSCs), intestinal stem cells (ISCs), satellite cells of the skeletal muscle, neural stem cells (NSCs), skin stem cells and germline stem cells (GSCs).
Researchers study secrets of aging via stem cells
2017年4月18日 · Scientists studying stem cell and regenerative biology are probing the secrets of aging, examining both whether decline is inevitable and how to fight the diseases that multiply with time.
Stem cell aging: mechanisms, regulators and therapeutic
2014年8月6日 · Here we explore key molecular pathways that are commonly perturbed as tissues and stem cells age and degenerate. We further consider experimental evidence both suppoxrting and refuting the...
A stem cell aging framework, from mechanisms to interventions - Cell …
2022年10月18日 · In this review, we elucidate aging-related features across different somatic stem cell types, with a specific focus on epigenetic changes, loss of protein homeostasis, and systemic influencing factors, including chronic inflammation, circadian rhythm dysregulation, and metabolic disorder.
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