Statin-Induced Myopathy: Types, Symptoms, and Risk Factors - Healthline
2022年5月16日 · Statin-induced myopathy is pain caused by statin medications that reduce risk of heart disease. We explain causes, symptoms, treatment, etc.
Drug-induced myopathies - UpToDate
2024年4月22日 · Although the precise incidence is unknown, drug-induced myopathy is a common cause of muscle disease. Clinical manifestations range from mild myalgia with no …
Statin muscle-related adverse events - UpToDate
2024年7月8日 · Muscle syndromes associated with statins include myalgias, myopathy, myositis, and muscle injury . The clinical and distinct histopathologic findings of these syndromes are …
Statin-induced myopathy: Definition, symptoms and treatment
2023年11月21日 · This article looks at what statin-induced myopathy is and the symptoms, causes, and risk factors for the condition. It also looks at treatment for statin-induced …
Statin-Associated Myopathy: Emphasis on Mechanisms and …
Statin-associated muscle symptoms (SAMS) are the most common side effect associated with treatment discontinuation. SAMS, which range from mild-to-moderate muscle pain, weakness, …
creatine kinase measurements show features of statin induced myopathy, first line management is to stop statins, observe symptoms, and monitor creatine kinase. A repeat challenge with …
What to Know About Statin-Induced Myopathy (Muscle Pain) - HealthCentral
2024年7月18日 · Statin-induced myopathy is muscle weakness or pain due to use of a cholesterol-lowering statin medication, potentially caused by muscle inflammation or damage.
Statin-Induced Myopathy: Symptoms, Causes, and Treatment
2023年8月23日 · Statin-induced myopathy is when statin medications cause muscle symptoms as a side effect. Symptoms can include weakness, pain, and fatigue. Changing your medications …
Statin-Associated Autoimmune Myopathy - The New England Journal of Medicine
2016年2月18日 · Statin-associated autoimmune myopathy is an exceptionally rare side effect of statin use. Its incidence is not known with certainty, but it is estimated to occur in...
Statin Toxicity | Circulation Research - AHA/ASA Journals
2019年1月18日 · Statins work by competitively blocking the active site of the first and key rate-limiting enzyme in the mevalonate pathway, HMG-CoA reductase. Inhibition of this site …
Statin induced myopathy - The BMJ
2008年11月6日 · In this review we discuss statin induced myopathy and its management in the light of recent epidemiological studies, randomised controlled trials, and guidelines. How …
Statin side effects: Weigh the benefits and risks - Mayo Clinic
2023年5月27日 · Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). Rhabdomyolysis can cause extreme muscle pain, …
Statin-Induced Autoimmune Necrotizing Myopathy - PMC
In statin-induced autoimmune myopathy, genetically predisposed and at-risk patients can develop antibodies against hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key enzyme in the …
Statin-induced myopathies - PubMed
Multiple pathophysiological mechanisms may contribute to statin myotoxicity. This review focuses on a number of them. The prevention of statin-related myopathy involves using the lowest …
Statin-induced myopathy: a review and update - PubMed
Introduction: Statin-induced myopathy is an important cause of statin intolerance and the most common cause of statin discontinuation. Observational studies estimate that 10 - 15% of statin …
Managing Statin-Associated Muscle Symptoms - American College of Cardiology
2017年5月3日 · Statin intolerance due to statin-associated muscle symptoms (SAMS) is low in randomized controlled trials (RCTs), but much higher in clinical observation studies. Statin …
Treatment Options for Statin-Associated Muscle Symptoms
Evaluation of muscle symptoms in 420 statin-naïve people in one prospective randomized trial revealed that the incidence of myalgia (muscle pain) was 9.4% for individuals taking 80 mg of …
Statin Safety and Associated Adverse Events: A Scientific …
2018年12月10日 · One in 4 Americans >40 years of age takes a statin to reduce the risk of myocardial infarction, ischemic stroke, and other complications of atherosclerotic disease.
Individualized risk for statin-induced myopathy - PubMed …
In this review, we summarize current knowledge regarding the genetic and non-genetic determinants of risk for statin induced myopathy. Many genetic factors were initially identified …
Statin-induced myopathy: a review and update - Taylor
2011年2月23日 · Expert opinion: There are multiple risk factors for statin-induced myopathy that are both patient-related (age, genetics, co-morbidities) and drug-related (statin metabolism via …