ANCHR mediates Aurora-B-dependent abscission checkpoint
2014年5月11日 · Pioneering work in both yeast and mammalian cells has identified the existence of an abscission checkpoint (also termed NoCut) that depends on Aurora kinase B (AURKB) and delays abscission to...
ESCRT-III Governs the Aurora B–Mediated Abscission ... - Science
2012年3月15日 · Midbody recruitment of ESCRT-III, the filament-forming scission machinery, is an essential event in cytokinesis that is thought to provide constrictive force during abscission (2, 10–12). An Aurora B–dependent abscission checkpoint (NoCut) is thought to retard abscission to prevent damage of lagging chromosomes that are trapped in the ...
The Aurora-B-dependent NoCut checkpoint prevents damage of ... - Nature
2016年4月25日 · The Aurora-B-dependent NoCut checkpoint was proposed to inhibit abscission in response to chromosome segregation defects in yeast and animal cells, to prevent DNA breakage by cytokinesis 13,14,18.
ESCRT-III Governs the Aurora B-Mediated Abscission Checkpoint …
2012年4月4日 · Here we found that CHMP4C acts as an essential regulator of the Aurora B-mediated abscission checkpoint. In the absence of CHMP4C, cells complete abscission faster. We suggest that Aurora B-dependent phosphorylation of CHMP4C upon S210 directs its Flemming-body localization and delays abscission through activation of NoCut, possibly by ...
The Aurora B specificity switch is required to protect from non ...
2020年3月13日 · The Aurora B abscission checkpoint delays cytokinesis until resolution of DNA trapped in the cleavage furrow. This process involves PKCε phosphorylation of Aurora B S227.
Aurora B-Mediated Abscission Checkpoint Protects against ...
2009年2月6日 · We found that Aurora B inactivation at the midbody promotes abscission. Chromosome bridges delayed abscission and sustained Aurora B activity to posttelophase, which was essential to stabilize Mklp1 at the intercellular canal and to suppress furrow regression.
Abscission checkpoint control: stuck in the middle with Aurora B
2012年7月1日 · The presence of chromatin bridges ‘stuck’ in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, triggering a checkpoint that delays abscission until the chromatin bridges have been resolved.
a human ESCRT-III subunit, is involved in abscission timing. This function correlated with its differential spatiotemporal distribution during late stages of cytokinesis. Accordingly, CHMP4C functioned in the Aurora B–dependent abscission checkpoint to prevent both premature resolution
Our study provides evidence that in human cells abscission is coordinated with the completion of chromosome segregation to protect against tetra-ploidization by furrow regression.
Cytokinetic Abscission: Molecular Mechanisms and Temporal …
In normally segregating cells, midbody-localized Aurora B is inactivated at the time of abscission, and chemical inhibition of Aurora B after cleavage furrow ingression accelerates abscission, indicating that Aurora B is not required for abscission per se, but rather functions as an inhibitor of abscission (Mathieu et al., 2013; Steigemann et ...