The enigma of embryonic diapause - The Company of Biologists
2017年9月15日 · Embryonic diapause – a period of embryonic suspension at the blastocyst stage – is a fascinating phenomenon that occurs in over 130 species of mammals, ranging from bears and badgers to mice and marsupials. It might even occur in humans. During diapause, there is minimal cell division and greatly reduced metabolism, and development is put on hold.
Developmental progression continues during embryonic diapause …
2024年3月5日 · Embryonic diapause in mammals is a temporary developmental delay occurring at the blastocyst stage. In contrast to other diapausing species displaying a full arrest, the blastocyst of the...
Under Arrest: The Embryo in Diapause - Cell Press
2020年1月27日 · Embryonic diapause is the reversible arrest in development of mammalian embryos at the blastocyst stage. In this issue of Developmental Cell, Hussein et al. reveal that alternative splicing of Lkb1 is essential for diapause to persist and find the elevation of glycolytic and lipolytic pathways that were previously considered dormant.
Mechanisms of animal diapause: recent developments from …
2016年6月1日 · The diapausing embryo serves as an overwintering stage during which development ceases and metabolism is severely depressed (30, 142). Some of the diapausing embryos are blown toward the shoreline in wind rows (streaks; Fig. 2 A ) where they accumulate on the bank and desiccate, while others remain in the lake and overwinter in the hydrated ...
Research advances on embryonic diapause in mammals
2018年11月1日 · Embryonic diapause occurs in over 130 species of mammals. In embryonic diapause, there is a reversible cessation phase in embryo development and subsequent reactivation and continuation of development with no adverse effects. This allows animals to prolong gestation and give birth to offspring at a more favorable time from a survival perspective.
Embryonic Diapause Is Conserved across Mammals | PLOS ONE
2012年3月12日 · Embryonic diapause (ED) is a temporary arrest of embryo development and is characterized by delayed implantation in the uterus. ED occurs in blastocysts of less than 2% of mammalian species, including the mouse (Mus musculus).
Program freezing of diapausing embryos in the mouse
2024年3月15日 · Embryonal diapause is a characteristic feature of about 130 mammalian species. However, very few studies have addressed cryopreservation of diapausing embryos. This work is aimed to apply program freezing to blastocysts obtained from CD1 mice, which were at diapause state after ovariectomy and the subsequent hormonal therapy.
Physiological strategies during animal diapause: lessons from …
2015年6月1日 · Diapause typically precedes the onset of adverse environmental conditions, and production of diapausing embryos is often induced by environmental factors that offer reliable cues for predicting future conditions, such as photoperiod or food quality/availability.
Embryonic Diapause and Maternal Recognition of Pregnancy in Diapausing ...
Embryonic diapause is a period of suspended animation of the mammalian embryo at the blastocyst stage. Importantly, the uterus is also quiescent, and it is clear that there is a great deal of crosstalk between blastocyst at the entry into diapause, the maintenance of diapause and the reactivation from diapause.
Program freezing of diapausing embryos in the mouse
2024年3月15日 · The aim of this work is to study the possibility of program freezing to cryopreserve diapausing mouse embryos. The developmental potential of frozen-thawed diapausing embryos was evaluated by the re-expanding of blastocoel cavity after in vitro culture (IVC) and verified by assessing protein metabolism and cell division after cryopreservation.