BCL6 - Wikipedia
BCL6 is found to be frequently translocated and hypermutated in diffuse large B cell lymphoma (DLBCL) [11] [12] [13] and contributes to the pathogenesis of DLBCL. BCL6 is exclusively present in the B-cells of both healthy and neoplastic (cancerous) germinal centers.
B-cell Lymphoma 6 (BCL6): From Master Regulator of Humoral …
2022年12月2日 · In this review, we summarize what is known of BCL6 (role, effect, mechanisms) in pediatric cancers, highlighting the two sides of BCL6 function, humoral immunity, and tumorigenesis, as well as to review BCL6 inhibitors and highlight areas of opportunity to improve the outcomes of patients with pediatric cancer.
BCL6 Gene - GeneCards | BCL6 Protein | BCL6 Antibody
2024年10月1日 · BCL6 (BCL6 Transcription Repressor) is a Protein Coding gene. Diseases associated with BCL6 include Intravascular Large B-Cell Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit. Among its related pathways are Gene expression (Transcription) and Cytokine Signaling in Immune system.
B-cell Lymphoma 6 (BCL6): From Master Regulator of Humoral
2022年12月2日 · B-cell lymphoma 6 (BCL6) is a protooncogene in adult and pediatric cancers, first identified in diffuse large B-cell lymphoma (DLBCL) where it acts as a repressor of the tumor suppressor TP53, conferring survival, protection, and maintenance of lymphoma cells.
B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity …
2024年10月11日 · BCL6 is critical for germinal center (GC) formation and the development of high-affinity antibodies, with key roles in the generation and function of GC B cells, follicular helper T (Tfh) cells, follicular regulatory T (Tfr) cells, and various immune memory cells.
BCL6: Master Regulator of the Germinal Center Reaction
2010年1月1日 · BCL6 is a transcriptional repressor which has emerged as a critical regulator of germinal centers (GC), the sites where B cells are selected based on the production of antibodies with high affinity for the antigen. BCL6 is also a frequently activated oncogene in the pathogenesis of human B cell lymphomas, most of which derive from the GC B cells.
A Hybrid Mechanism of Action for BCL6 in B Cells Defined by …
2013年8月15日 · Elemento, Melnick, and colleagues examine mechanisms by which the BCL6 transcriptional repressor mediates its critical survival and proliferation functions in B cell lymphomas and germinal center B cells. BCL6 regulates one set of genes by forming hybrid Polycomb/HDAC promoter complexes with SMRT/NCOR and BCOR corepressors.
B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity
2024年10月11日 · B cell lymphoma 6 (BCL6) is a conserved multi-domain protein that functions principally as a transcriptional repressor. This protein regulates many pivotal aspects of immune cell development and function. BCL6 is critical for germinal center (GC) formation and the development of high-affinity antibo ….
Roles of BCL6 in normal and transformed germinal center B cells
2012年4月13日 · Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells. BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells.
A Signaling Pathway Mediating Downregulation of BCL6 in …
2007年9月11日 · Post-GC development of B cells requires BCL6 downregulation, while its constitutive expression caused by chromosomal translocations leads to diffuse large B cell lymphoma (DLBCL). Herein we identify a signaling pathway that downregulates BCL6 expression in normal GC B cells and is blocked in a subset of DLBCL due to alterations in the BCL6 gene.