Lipid-droplet-accumulating microglia represent a dysfunctional …
2020年1月20日 — Here we report a striking buildup of lipid droplets in microglia with aging in mouse and human brains. These cells, which we call ‘lipid-droplet-accumulating microglia’ (LDAM), are...
Microglial REV-ERBα regulates inflammation and lipid droplet
2023年8月25日 — Here, we show that microglial REV-ERBα deletion enhances inflammatory signaling, disrupts lipid metabolism, and causes lipid droplet (LD) accumulation specifically in male microglia. These events...
APOE4/4 is linked to damaging lipid droplets in Alzheimer’s …
2024年3月13日 — In human induced pluripotent stem cell-derived microglia, fibrillar Aβ induces ACSL1 expression, triglyceride synthesis and lipid droplet accumulation in an APOE-dependent manner....
Lipid-droplet-accumulating microglia represent a dysfunctional …
Here we report a striking buildup of lipid droplets in microglia with aging in mouse and human brains. These cells, which we call 'lipid-droplet-accumulating microglia' (LDAM), are defective in phagocytosis, produce high levels of reactive oxygen species and …
Dynamic Brain Lipid Profiles Modulate Microglial Lipid Droplet ...
Lipid droplet (LD) accumulation in microglia results in a dysfunctional and pro-inflammatory state in the aged brain and worsens the outcome of neuroinflammatory and neurodegenerative diseases. However, the role of LD-rich microglia (LDRM) under stroke conditions is unknown.
TREM2 regulates microglial lipid droplet formation and represses …
2024年1月1日 — In these lipid droplet-rich microglia, the TGF-β1/Smad2/3 signaling pathway is downregulated, driving microglia towards a pro-inflammatory phenotype. Meanwhile, in a neuron-microglia co-culture system under hypoxic conditions, we found that microglia lost their protective effect against neuronal injury and apoptosis when TREM2 was knocked down.
Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation
These data suggest that microglial-LPL is associated with lipid uptake, which may drive PPAR signaling and cholesterol efflux to prevent inflammatory lipid distribution and LD accumulation. Moreover, PPAR agonists can reverse LD accumulation, and therefore may be beneficial in aging and in the treatment of NDs.
Microglia and lipids: how metabolism controls brain innate immunity
2021年4月1日 — These opposing phenotypes illustrate how lipid composition and distribution in LDs is essential to the control of microglial responses. A recent study reported a buildup of LDs in a defined microglial population in aged mouse and human brains, called “lipid droplet-accumulating microglia” (LDAM) [25]. LDAM presented impaired phagosome ...
ANGPTL4-mediated microglial lipid droplet accumulation: …
2024年11月20日 — Recent evidence suggests that lipid droplet accumulation in microglia may be associated with an increased risk of developing AD (Sarabi et al., 2024). Building upon the bioinformatics findings mentioned earlier, we simulated a high-fat environment using palmitic acid and oleic acid to explore the impact of free fatty acid overload on the ...
Microglial lipid droplet accumulation in tauopathy brain is …
2024年6月4日 — Transfer of unsaturated lipids from tauopathy iPSC neurons to microglia induced LD accumulation, oxidative stress, inflammation, and impaired phagocytosis. Neuronal AMP-activated protein kinase (AMPK) inhibits lipogenesis and promotes lipophagy in neurons, thereby reducing lipid flux to microglia.