Intracellular lipid droplet accumulation occurs early following …
2021年7月14日 — Lipid droplets (LDs) are increasingly recognized as critical organelles in signalling events, transient protein sequestration and inter-organelle interactions. However, the role LDs play in...
Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger ...
Zhang et al. describe the role of AUP1, a lipid droplet-associated host factor that is exploited during flavivirus infections. Viral non-structural proteins NS4A and NS4B interact with AUP1 to hijack its acyltransferase function, triggering the consumption of lipid droplets to facilitate production of progeny virus particles.
Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger ...
2018年6月13日 — Our results show that DENV-NS4A exploits the acyltransferase activity of AUP1 to trigger lipophagy, a process regulated by ubiquitylation. This mechanism appears to be a general phenomenon in biogenesis of flaviviruses and underscores the critical role of post-translational modifications in virus infections.
Glycerophospholipid remodeling is critical for orthoflavivirus
2024年10月7日 — Flavivirus infection is tightly connected to host lipid metabolism. Here, we performed shotgun lipidomics of cells infected with neurotropic Zika, West Nile, and tick-borne encephalitis virus,...
Modulation of Lipid Droplet Metabolism—A Potential Target for ...
2017年11月27日 — Lipid droplets (LDs) are endoplasmic reticulum (ER)-related dynamic organelles that store and regulate fatty acids and neutral lipids. They play a central role in cellular energy storage, lipid metabolism and cellular homeostasis. It has become evident that viruses have co-evolved in order to exploit host lipid metabolic pathways.
Viral subversion of selective autophagy is critical for biogenesis of ...
2023年5月10日 — We previously identified that virus-triggered lipophagy was critical for flaviviral assembly, and is driven by the lipid droplet associated protein Ancient ubiquitin protein 1 (Aup1). A...
Lipid Droplets: Formation, Degradation, and Their Role in Cellular ...
2024年3月24日 — Lipid droplets (LDs) are cellular organelles derived from the endoplasmic reticulum (ER), serving as lipid storage sites crucial for maintaining cellular lipid homeostasis. Recent attention has been drawn to their roles in viral …
Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger ...
2018年6月1日 — Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production. An exquisite fine-tuning of selective autophagy by flaviviruses that drive host membrane reorganization during infection to enable biogenesis of viral replication organelles is …
Multifaceted Nature of Lipid Droplets in Viral Interactions and ...
2023年7月21日 — The NDRG1-DGAT1/2 pathway has been found to play a critical role in the exacerbation of lipid droplets during rabies virus infection. In addition, pharmacological inhibition of lipid droplet formation by inhibiting the enzyme HMG-CoA reductase with atorvastatin has been found to reduce lipid droplet formation and decrease viral particle production.
Lipids and flaviviruses, present and future perspectives for the ...
2016年10月1日 — Flavivirus infection modifies lipid droplets and there are evidences for the reduction of lipid droplets within infected cells by the utilization of these organelles via lipophagy [72] or reabsorption into the ER [65].