Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 …
The hall mark of human immunodeficiency virus (HIV) infection is a gradual loss of CD4+ T-cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity that leads ultimately to death. HIV infection in humans is caused by ...
为什么HIV特异性感染CD4+ T细胞？ - 知乎
2017年3月28日 — HIV进入健康的人体后能选择性的侵犯有CD4受体的淋巴细胞，其中以CD4+ T淋巴细胞为主，当HIV的包膜蛋白gp120与CD4十T细胞表面的CD4受体结合后，在gp41透膜蛋白的协助下，HIV的膜与细胞膜相融合，病毒进入细胞内，并迅速脱去外壳。 HIV病毒在宿主细胞开始复制，首先两条RNA在病毒逆转录酶的作用下逆转为DNA，再以DNA为模板，在DNA多聚酶的作用下复制DNA，这些DNA部分存留在细胞浆内，进行低水平复制，部分与宿主细胞核的染色质 …
CD4+ T cell depletion in HIV infection: mechanisms of immunological ...
The major barrier to eradication of HIV is thought to be the pool of latently infected, long-lived, resting CD4 + memory T cells, including both CD4 + T CM and T TrM cells, that constitute the major cellular reservoirs for HIV persistence in patients on ART .
Dissecting How CD4 T Cells Are Lost During HIV Infection
Pyroptosis provides a nexus between CD4 T cell death and inflammation—the two key drivers of HIV pathogenesis. Abortive HIV infection of CD4 T cells in lymphoid tissues results in sensing of the viral cytosolic DNA products by IFI16 leading to caspase-1 activation in inflammasomes and pyroptosis (steps 1 and 2).
CD4+ T cell signatures in HIV infection | Nature Immunology
2019年7月15日 — Analysis of the whole-genome transcriptional activity of HIV-specific CD4 + T cells demonstrates distinct profiles associated with natural control of HIV replication, as well as dysfunctional...
Acquired Immune Deficiency Syndrome CD4+ Count
2023年8月14日 — HIV is a fatal infection, characterized by the targeting and destruction of CD4 T lymphocytes in the peripheral blood. CD4 T lymphocytes are a part of the human T-lymphocyte cells that are produced in the bone marrow and eventually mature in the thymus. They circulate the body to fight against bacteria, viruses, and other organisms.
Chronic inflammation degrades CD4 T cell immunity to prior
3 天之前 — A Percentages of CD69 + CD3, CD4 or CD8 T cells after stimulation of PBMCs from uninfected (HU) or HIV-infected (HIV) groups with MV, TT or SEB. B Percentages of IFNγ +, IL-2 + and TNF + CD3, CD4 ...
认识和了解HIV感染诊断和疾病进展的预测指标——CD4+T细胞
在hiv感染和疾病进展的过程中，cd4+t细胞是表达cd4分子的辅助性t淋巴细胞，它既是发挥抗hiv病毒免疫作用的主要细胞，也是hiv病毒攻击的靶细胞，因此对于cd4+t细胞的检测是进行hiv感染和aids的分期和判断疗效的主要指标。
Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 …
2017年5月22日 — In this article, we review the distinct pathological differences between HIV-1 and HIV-2 infections in the perspective of differential rate of CD4+ T-cell decline and provide plausible reasons for the observed differences.
CD4 + T Cell Subsets and Pathways to HIV Latency - National …
2018年9月9日 — Latent infection of CD4 + T cells is the main barrier to eradicating HIV-1 infection from infected patients. The cellular and molecular mechanisms involved in the establishment and maintenance of latent infection are directly linked to the transcriptional program of the different CD4 + T cell subsets targeted by the virus.