Mac-1 (CD11b/CD18) is essential for Fc receptor–mediated …
2001年4月15日 · Mac-1 (complement receptor type 3, CD11b/CD18) has previously been implicated in receptor cooperation with Fc receptors (FcRs). The role of Mac-1 in FcR-mediated lysis of tumor cells was characterized by studying normal human PMNs, Mac-1–deficient mouse PMNs, and mouse PMNs transgenic for human FcR.
A ligand-specific blockade of the integrin Mac-1 selectively ... - Nature
2018年2月6日 · Here, we report a novel monoclonal antibody, anti-M7, that specifically blocks the interaction of the integrin Mac-1 with its pro-inflammatory ligand CD40L, while not interfering with alternative...
LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate …
2019年4月9日 · Precise spatiotemporal regulation of leukocyte extravasation is key for generating an efficient immune response to injury or infection. The integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18)...
A DARPin targeting activated Mac-1 is a novel diagnostic tool and ...
Using phage display, a Designed-Ankyrin-Repeat-Protein (DARPin) was selected as a novel binding protein targeting and blocking the α M I-domain, an activation-specific epitope of Mac-1. This DARPin, named F7, specifically binds to activated Mac-1 on mouse and human monocytes as determined by flow cytometry.
A ligand-specific blockade of the integrin Mac-1 selectively …
2018年2月6日 · Here, we report a novel monoclonal antibody, anti-M7, that specifically blocks the interaction of the integrin Mac-1 with its pro-inflammatory ligand CD40L, while not interfering with alternative ligands. Anti-M7 selectively reduces leukocyte recruitment in vitro and in vivo.
Leukocyte integrin Mac-1 regulates thrombosis via interaction …
2017年5月30日 · Our data identify a new pathway of thrombosis involving leukocyte Mac-1 and platelet GPIbα, and suggest that targeting this interaction has anti-thrombotic therapeutic potential with reduced...
Leukocyte Integrin Mac-1 Recruits Toll/Interleukin-1 Receptor ...
2001年11月9日 · We found that Mac-1 clustering induced the expression of genes encoding for cytokines, chemokines, transcription factors, signaling intermediates, and numerous expression sequence tags.
Critical role of the Mac1/NOX2 pathway in mediating reactive ...
This review focuses on how the microglial integrin receptor Mac1 and its downstream effector NADPH oxidase (NOX2) contribute to maintaining chronic neuroinflammation and are crucial in inflammation-driven neurotoxicity in neurodegenerative diseases.
Structural basis of the leukocyte integrin Mac-1 I-domain …
2019年5月5日 · Cell-surface receptor interactions between leukocyte integrin macrophage-1 antigen (Mac-1, also known as CR3, αMβ2, CD11b/CD18) and platelet glycoprotein Ibα (GPIbα) are critical to vascular inflammation.
Mac-1 (CD11b/CD18) is crucial for effective Fc receptor–mediated ...
2003年1月1日 · In summary, this study documents Mac-1 to be required for FcR-mediated antimelanoma immunity in vivo and, furthermore, supports a role for neutrophils in melanoma rejection. Antibody (Ab)–dependent cellular cytotoxicity (ADCC) is considered crucial for Ab-mediated tumor cell degradation.