Acute myeloid leukemia: Pathogenesis - UpToDate
2022年3月8日 — Acute myeloid leukemia (AML) develops as the consequence of a series of genetic changes in a hematopoietic precursor cell. These changes alter normal hematopoietic growth and differentiation, resulting in an accumulation of large numbers of abnormal, immature myeloid cells in the bone marrow and peripheral blood.
Acute Myeloid Leukemia - StatPearls - NCBI Bookshelf
2024年4月27日 — Acute myeloid leukemia (AML) is a rapidly progressing myeloid neoplasm characterized by the clonal expansion of immature myeloid-derived cells, known as blasts, in the peripheral blood and bone marrow. This expansion results in ineffective erythropoiesis and megakaryopoiesis, clinically manifesting as relatively rapid bone marrow failure compared to chronic and indolent leukemias. This leads ...
Pathophysiology of Acute Myeloid Leukemia - PubMed
Pathophysiology of Acute Myeloid Leukemia Acta Haematol. 2024;147(2):229-246. doi: 10.1159/000536152. Epub 2024 Feb 16. Authors ... Background: Acute myeloid leukemia (AML) is a biologically heterogenous disease arising in clonally proliferating hematopoietic stem cells. Sequential acquisition of mutations leads to expanded proliferation of ...
Acute Myeloid Leukemia (AML) - Acute Myeloid Leukemia (AML…
Acute Myeloid Leukemia (AML) - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals ... Pathophysiology of AML. Similar to acute lymphoblastic leukemia, acute myeloid leukemia is caused by a series of acquired genetic aberrations. Malignant transformation usually occurs at the pluripotent stem cell level ...
An update on the molecular pathogenesis and potential therapeutic ...
2020年1月14日 — Acute myeloid leukemia (AML) with t(8;21)(q22;q22.1);RUNX1-RUNX1T1, one of the core-binding factor leukemias, is one of the most common subtypes of AML with recurrent genetic abnormalities and is associated with a favorable outcome.The translocation leads to the formation of a pathological RUNX1-RUNX1T1 fusion that leads to the disruption of the normal function of the core-binding factor ...
The Molecular Pathology of Acute Myeloid Leukemia
2005年1月1日 — The pathogenesis of acute myelogenous leukemia (AML) involves an array of molecular alterations that disrupt almost every facet of cell transformation. These processes include the regulation of cell proliferation, differentiation, self-renewal, survival, cell cycle checkpoint control, DNA repair and chromatin stability, and cell dissemination.
‘Acute myeloid leukemia: a comprehensive review and 2016 …
Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with an incidence of over 20 000 cases per year in the United States alone. ... Regardless of its etiology, the pathogenesis of AML involves the abnormal proliferation and differentiation of a clonal population of myeloid stem cells. Well-characterized chromosomal ...
Pathogenic Mechanisms in Acute Myeloid Leukemia
2022年10月3日 — Acute myeloid leukemia (AML) is the most common form of leukemia in adults, leading to the highest number of annual leukemia-associated deaths in the USA. Although most AML patients initially enter remission following induction therapy, most eventually relapse, underscoring the unmet need for more effective therapies. In recent years, novel high-throughput sequencing techniques, and mouse and ...
The molecular pathogenesis of acute myeloid leukemia
The description of the molecular pathogenesis of acute myeloid leukemias (AML) has seen dramatic progress over the last years. Two major types of genetic events have been described that are crucial for leukemic transformation: alterations in myeloid transcription factors governing hematopoietic differentiation and activating mutations of signal transduction intermediates.
Acute Myeloid Leukemia (AML): Practice Essentials, Pathophysiology …
Acute myeloid leukemia (AML) is a malignant disease characterized by the abnormal proliferation and differentiation of myeloid precursors in the bone marrow. AML is the most common form of leukemia in adults, with most cases occurring in individuals over the age of 60 years. ... Wachter F, Pikman Y. Pathophysiology of Acute Myeloid Leukemia ...