For their proof of concept, they worked with the EGFR gene, which is central to the development of various types of cancer, including lung, brain and breast cancer. Platt and his team combined two ...

TYK Medicines Inc. has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase-binding moiety covalently bonded to an EGFR (mutant)-targeting moiety through a ...

China’s drug regulator approved Alpha Biopharma Ltd.’s EGFR tyrosine kinase inhibitor (TKI), Zorifer (zorifertinib hydrochloride tablets; AZD-3759), as a first-line treatment for EGFR-mutated ...

Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR is involved in several cancer developments, including NSCLC. The EGFR pathway regulates the Bax/Bcl-2 cascade in ...

"We manufacture so-called 'gene ferries,' into which all kinds of ... The specific focus was on how changes in polymer structure and environmental conditions impact particle formation.

Editing Without 'Cutting': Molecular Mechanisms of New Gene-Editing Tool Revealed May 29, 2024 — New research has determined the spatial structure of various processes of a novel gene-editing ...

Sunvozertinib has shown promising results in patients with non–small cell lung cancer with an EGFR exon 20 insertion mutation. The new drug application (NDA) of sunvozertinib in relapsed/refractory ...

Researchers in Lithuania present the molecular structure of a new, more-versatile CRISPR system for gene editing. Scientists have unveiled a new version of the famous gene-editing tool CRISPR ...