mRNA levels of certain of the cytokines correlated with Wnt signaling components. In addition, the increased serum TNF- α in T2D was associated with reduced Young's modulus, a measure of bone strength ...

However, there are no data about adiponectin in bone of subjects with T2D or obesity. We also showed that subjects with T2D had increased SFRP5 bone mRNA levels compared to controls. Data reported ...

Perturbation experiments in GC tumour cell lines and xenograft models further demonstrated that HNF4α is downregulated by AMPKα signalling and the AMPK agonist metformin; blockade of HNF4α activity ...

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Mahama pledges to revive Afram River bridge project to boost regional developmen ...

Functional study demonstrated that secreted Wnt2 could promote oesophageal cancer cell growth by activating the Wnt/β-catenin signalling pathway and subsequently upregulated cyclin D1 and c-myc ...

A plugin to launch applications from the panel. By default it is empty and displays a message "Drop application icons here". Applications need to be available in panel's main menu and can be included ...

Build financial models with decades of earnings stats, ratios, and valuation data — all exportable — to power your trade ideas.

Morphogens are diffusible molecules that elicit signalling responses in surrounding cells in a concentration dependent manner. They modulate gene expression in a graded manner to provide ...

Cell signalling is the mechanism by which stimuli are transmitted via a signalling cascade to effector molecules that orchestrate the appropriate response. Types of cell signalling pathways ...

The first patients have been dosed in a phase 3 trial of an mRNA-based seasonal influenza vaccine developed by Pfizer and BioNTech, which may offer quicker production and greater efficacy than ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction ...