The cancer microenvironment, or tumour microenvironment, describes the non-cancerous cells present in the tumour. These include fibroblasts, immune cells and cells that comprise the blood vessels.

So far, no treatment has been able to make this aggressive tumor permanently disappear. The tumor cells are too varied, and the microenvironment ... Tumor Suppressor Protein Par-4 Triggers Unique ...

The tumor microenvironment (TME) is one of the most formidable obstacles in the fight against cancer. While therapies that target cancer cells have been revolutionary, many patients still do not ...

Several studies have pointed out that the complex intercellular communication network in the immune microenvironment of HCC regulates tumor escape and ... including regulatory T (Treg) cells, ...

Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...

Amit Sharma as the first author, has identified GLUT3, a glucose transporter, as essential to the suppressive function of regulatory T cells (Tregs) in the tumor microenvironment (TME).

2The University of Texas MD Anderson Cancer Center, UTHealth Houston Graduate School of Biomedical Sciences (GSBS), Houston, Texas. 3Department of Genomic Medicine, The University of Texas MD Anderson ...

Sensei’s lead product candidate is SNS-101, a conditionally active antibody designed to block the V-domain Ig suppressor of T cell activation (VISTA) checkpoint selectively within the low pH tumor ...