Placental development is a multifaceted process critical for a fruitful pregnancy, reinforced by a complex network of molecular pathways that synchronize trophoblast migration, differentiation, and ...

The outer membrane (chorion) and trophoblast layer of the placenta are derived from the trophoectoderm of the blastocyst cells. Other extra-embryonic tissues, including the amnion (inner membrane ...

PE is thought to result from a combination of factors, including inflammatory cytokines, trophoblast dysfunction, and environmental influences, which may trigger epigenetic changes, particularly DNA ...

A signal that the body adds to an mRNA can disrupt placental development and lead to fetal growth restriction (FGR). In this ...

The evidence for the authors' claims is convincing, combining state-of-the-art conditional gene deletion in the mouse lens with histological and molecular approaches. This work should be of great ...

which were subsequently validated in trophoblast cell lines and relevant gene knockout mice. In early pregnancy, patients with preeclampsia exhibit decreased peripheral blood irisin levels, occurring ...

研究胎盘发育机制对深入探究人类孕早期特征和女性生殖健康意义重大。科学家通过构建“迷你胎盘”（滋养层细胞类器官）揭示出胎盘发育过程及其与子宫内膜的相互作用。相关研究成果刊发在《Cell Stem ...