Transmembrane proteins are frequently the primary targets ... A deep understanding of the 3D structure and functional mechanisms of these proteins is essential for developing novel antibody ...

Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone receptor ...

Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone receptor for the first time, uncovering how it functions, which may enable better ...

The endoplasmic reticulum (ER)-localized transmembrane proteins IRE1, PERK and ATF6 detect the load of unfolded protein in the lumen of the organelle, serving as stress receptors. They transduce ...

Behold the Body. Electron microgram of a Biondi body shows a dense core surrounded by filaments that bind gold-labeled secondary antibody to TMEM239 (black dots). [Courtesy of Ghetti et al., 2024.] ...

The OSCA1.2 L438K mutation structure was modeled using 6MGV as the template, and the RMSD between the mutation and the original structure of 6MGV was less than 0.5 Å. To mimic the state of ...

Toolbox for molecular animations in Blender, powered by Geometry Nodes.

The latest version of Google DeepMind and Isomorphic Labs’ AlphaFold model can predict the structure and relationships not only of proteins, but “all of life’s molecules”, according to its ...