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“We’ve found a molecular basis for the yo-yo effect,” said Ferdinand von Meyenn, professor of nutrition and metabolic epigenetics at ETH Zurich University in Switzerland. New research finds ...

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The researchers, led by Hinte, von Meyenn, and their colleague Daniel Castellano Castillo, a former postdoc in von Meyenn's group, looked for the molecular causes of the yo-yo effect in mice.

ETH Zurich researchers have identified an epigenetic memory in fat cells that drives the yo-yo effect after weight loss. Studies in mice and humans reveal that fat cells retain obesity markers, making ...