When a vertebrate embryo develops, a group of cells self-organizes into the neural tube, eventually becoming the brain and the spinal cord. This involves specific signals, but how these signals are ...

Credit: Yuichiro Chino/Moment via What researchers know of human cells is pieced together like a scrapbook full ...

Scientists at Queen Mary University of London and the University of Hong Kong have created a mouse with substituted genes ...

To this end, they developed a novel embryo-like model system consisting of a layer of epiblast and a layer of VE cells—a cup without a lid. They achieved this with the targeted and controlled ...

iPSCs have the same properties as embryonic stem cells, and therefore self ... are able to stably engraft and generate glia cells in transplanted mouse brains with no evidence of tumor formation.

The protein netrin1 has an entirely unanticipated role in organizing the spinal cord during early development.

We all start our lives as symmetric balls of cells. In humans, during the first few weeks after fertilization, embryonic ...

Researchers have uncovered an unexpected role for the molecule netrin1 in organizing the developing spinal cord.

This unexpected discovery prompted Butler's team to explore further. In gain-of-function experiments with chicken and mouse embryos, along with mouse embryonic stem cells, they introduced a traceable ...