According to Alnylam’s Tim Mooney, mivelsiran’s endurance is due to stabilizing tweaks the scientists made to the siRNA ...

This study presents important findings on the role of CXXC-finger protein 1 in regulatory T cell gene regulation and function. The evidence supporting the authors' claims is solid, with mostly ...

A Golden Gate-based dual-expression vector enables rapid screening, which facilitates efficient isolation of high-affinity cross-reactive antibodies for therapeutic or diagnostic use and provides a ...

suggesting the accumulation of antibodies as an aging hallmark and the potential of IgG as a biomarker of aging. In human and ...

The discovery and optimization of antibodies, whether through traditional methods or with the assistance of artificial intelligence, necessitates rapid and reliable data generation. Here we introduce ...

A team of researchers at KU Leuven and VIB explored the molecular sequence of events in this ... prevent the loss of nerve cells in different mouse models of the disease. The findings open up ...

He then used two different technologies—flow cytometry and RNA sequencing—to find ... After unlocking the combination of specific antibodies required to detect all cell types, he and his ...

Using a mouse model, the researchers showed that ... allowing it to constantly change its protective surface coat and evade antibodies. The discovery, reported October 30 in Nature, could ...

The team also found that an existing monoclonal antibody that binds to this protein ... on differences in their species-specific FcRn's sequence, meaning that in some cases, this protein will ...