MG132 offset the effect of empagliflozin on NLRP3 degradation; coimmunoprecipitation assay confirmed that empagliflozin promotes the degradation of NLRP3 through the ubiquitin-proteasome system (all ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The functions of integrins are tightly ...

Mechanism studies revealed that syndecan‐4 induces PASMC proliferation by interacting and regulating protein kinase C α ubiquitination. In addition, syndecan‐4 was enriched in exosomes secreted from ...

An in vivo ubiquitination assay was performed with various Nedd4L constructs (each 0.5 µg ... and 1 µg/ml pepstatin A) containing 40 µM MG132. Cells were solubilized at 4 °C for 1 h on a rotating ...

However, the mechanism by which the functional stability of DBC1 is regulated has yet to be elucidated. Here, we report that the ubiquitination-mediated degradation of DBC1 is regulated by the E3 ...

Although post-translational modification of cellular proteins with ubiquitin is a key molecular mechanism governing protein degradation and function, mGlu7 ubiquitination and its functional ...