But what about long-term outcomes for patients ... withdrew because of drowsiness. Daily use of an intranasal steroid was superior to daily antihistamine therapy in patients with perennial rhinitis.

“If you take diphenhydramine, also known as Benadryl or Elavil, or any sort of antihistamine medication or anticholinergic for a long period of time, it has been linked to dementia,” Hasan said.

Here, allergists share the possible risks of long-term antihistamine use, the safest antihistamines to use daily and ...