This work is a continuation of a previous paper from the Arnold group, where they engineered GFE3, which allows to specifically ablate inhibitory synapses. Here, the authors generate 3 different ...

Excitatory synapses send signals that encourage the creation of an action potential by the next neuron; inhibitory synapses work against it. Each neuron receives signals from both excitatory and ...

Single-synapse imaging in neuronal ensembles should bridge the gap between molecular and systems neuroscience and holds considerable ... Recent advances in imaging technology, together with the ...

A groundbreaking study has used patient-derived stem cells to recreate a rare genetic form of autism in the lab.

Evidence for the effects of sex hormones on inflammation, myelination and neurodegeneration has implications for both cisgender and gender-diverse individuals with multiple sclerosis. Here, the ...

Rapid-acting antidepressant interventions, such as ketamine and psilocybin, are thought to enhance neural plasticity. This Review outlines evidence of synaptic deficits in individuals with major ...