"The study resulted in the discovery of KNDY (kisspeptin, neurokinin B (NKB), and dynorphin (A)) neurons around 15 years ago. The neurons are a critical part of the brain controlling puberty ...

Therefore, we investigated a series of dynorphin B (DynB) variants, substituted in one or two positions with naturally occurring amino acids for differential opioid receptor activation, applying ...

Neurokinin B (NKB) signaling is critical for reproduction in all studied species. The existing consensus is that NKB induces GnRH release via kisspeptin (Kiss1) stimulation in the arcuate nucleus.