A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the ...

InSTAnT keeps tabs on this activity, investigating where and how these workers interact, and what they might be up to. So, ...

The patent filing expands upon data obtained from animal model testing and the istaroxime human clinical trials in acute heart failure (AHF) and early cardiogenic shock (ECS), including the latest ...

Insights into protein synthesis processes in prokaryotes and eukaryotes are crucial for advancements in genetics, ...

The rNLS8 model is a twofold transgenic model in which human TDP-43 expression is suppressed by doxycycline (Dox) and has a ...

Protein synthesis in eukaryotic cells found in plants, animals, and fungi involves more than just the straightforward ...

A UT Southwestern trial found selinexor, an FDA-approved drug, effective in KRAS-mutated non-small cell lung cancer (NSCLC).

Using an innovative approach, EMBL scientists uncovered key interactions between molecular machines, potentially opening new avenues for drug development. Choosing a film for a movie night is always a ...

This useful study highlights the largely redundant role of the decapping activators Edc3 and Scd6 in orchestrating post-transcriptional programs to modulate metabolic responses to nutrients in yeast.

In these microorganisms, the MalF part of the protein helps with translocating LacZ from the cytoplasm to the cell envelope.