Conclusion. Ceftobiprole is a novel, broad-spectrum, parenteral cephalosporin undergoing Phase III clinical trials. Its broad spectrum of activity makes it a candidate for monotherapy of cSSSIs ...

Many authors have suggested using a cephalosporin as an alternative to penicillin. Casey and Pichichero performed a meta-analysis of 35 randomized, controlled trials comparing penicillin with ...

Chemical synthesis is the process by which one or more chemical reactions are performed with the aim of converting a reactant or starting material into a product or multiple products. Chemical ...

Enzymatic desaturation and reduction processes enable the synthesis of either enantiomer of the enone products from cyclohexanone or cyclohexadienone substrates. See Zeng et al. A flux-regulated ...

This important study will allow for a better understanding of anthelmintic drug resistance in nematodes, a growing concern for public health. The authors provide a detailed analysis of the role of UBR ...

A group of young students became bonafide biomedical scientists before they even started high school. Through a partnership with a nearby university, the middle schoolers collected and analyzed ...

Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

The results of such a review will hopefully provide a comprehensive synthesis of the available evidence ... Exposure to any class of antibiotics during pregnancy—including (but not limited to) ...

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan ...

Background: The emergence of multidrug-resistant bacteria and also biofilm-associated infections is a great health concern due to the failure of available antibiotics. This has alerted scientists to ...

The API market is primarily driven by the rising prevalence of chronic diseases, increasing demand for generic drugs, and advancements in drug manufacturing technologies. The growing adoption of ...

The discovery of changes in the chemical structure of quinolones significantly changes their antimicrobial activity, allowing the synthesis of other compounds of this family. The position 1 (Figure 1) ...