Purpose: The effects of extreme temperatures on drug delivery of two albuterol sulfate hydrofluoroalkane, metered-dose inhalers (MDIs ... temperatures had a modest increase in propellant-leak ...

The Ventolin HFA test MDIs also had an increased leak rate compared ... dose per actuation for both MDIs is 108 µg of albuterol sulfate, which corresponds to 90 µg of albuterol base.