For their proof of concept, they worked with the EGFR gene, which is central to the development of various types of cancer, including lung, brain and breast cancer. Platt and his team combined two ...

TYK Medicines Inc. has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase-binding moiety covalently bonded to an EGFR (mutant)-targeting moiety through a ...

China’s drug regulator approved Alpha Biopharma Ltd.’s EGFR tyrosine kinase inhibitor (TKI), Zorifer (zorifertinib hydrochloride tablets; AZD-3759), as a first-line treatment for EGFR-mutated ...

"We manufacture so-called 'gene ferries,' into which all kinds of ... The specific focus was on how changes in polymer structure and environmental conditions impact particle formation.

Editing Without 'Cutting': Molecular Mechanisms of New Gene-Editing Tool Revealed May 29, 2024 — New research has determined the spatial structure of various processes of a novel gene-editing ...

Study uses spatial transcriptomics to map intratumoral heterogeneity and microenvironmental dynamics in triple-negative ...

Oct. 28, 2024 — Using state-of-the-art technology, researchers have identified several specific steps needed for CRISPR to become active and perform its gene editing function. These preclinical ...

Sunvozertinib has shown promising results in patients with non–small cell lung cancer with an EGFR exon 20 insertion mutation. The new drug application (NDA) of sunvozertinib in relapsed/refractory ...