Transmembrane proteins are frequently the primary targets ... A deep understanding of the 3D structure and functional mechanisms of these proteins is essential for developing novel antibody ...
Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone receptor for the first time, uncovering how it functions, which may enable better ...
Extracellular signals perceived by 7-transmembrane (7TM)-spanning receptors initiate desensitization that involves the removal of these receptors from the plasma membrane. Agonist binding often evokes ...
The article broadly covers the integration of deep learning techniques in the field of protein structure prediction, highlighting notable advances and comparing them to traditional computational ...
The OSCA1.2 L438K mutation structure was modeled using 6MGV as the template, and the RMSD between the mutation and the original structure of 6MGV was less than 0.5 Å. To mimic the state of ...