Th17, Tregs and neutralizing Abs). Rightly so, however, from the results of the different GWASs summarized in the present article, a largely unexplored or poorly understood role of innate immunity ...

RANKL has essential roles in the formation of mammary gland and lymphoid organs by stimulating proliferation or differentiation ... Tumor infiltrating Tregs express RANKL, which promotes bone ...

Additionally, there is an imbalance between T-helper 17 (Th17) cells and regulatory T (Treg) cells, with a lower Treg/Th17 ratio being linked to worse outcomes. Metabolic reprogramming is a ...