However, Th17 cells also promote inflammation and have been implicated in the pathogenesis of many experimental autoimmune diseases and human inflammatory conditions. Transforming growth factor β ...

Th17, Tregs and neutralizing Abs). Rightly so, however, from the results of the different GWASs summarized in the present article, a largely unexplored or poorly understood role of innate immunity ...

Additionally, there is an imbalance between T-helper 17 (Th17) cells and regulatory T (Treg) cells, with a lower Treg/Th17 ratio being linked to worse outcomes. Metabolic reprogramming is a ...

Antigen-specific T helper and NKT cells, homeostatically restrained by Treg cells, contribute to intestinal inflammation and their influx can be therapeutically targeted. Work in the Kaser lab is ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...

3 An important pathological process increasingly recognised as driving intestinal inflammation and autoimmunity is the loss of immune homeostasis secondary to qualitative or quantitative defects in ...

Detecting danger is key to the survival and success of all species. Animal nervous and immune systems cooperate to optimize danger detection. Preceding studies have highlighted the benefits of ...

This study presents important findings on the role of CXXC-finger protein 1 in regulatory T cell gene regulation and function. The evidence supporting the authors' claims is solid, with mostly ...