The San Francisco 49ers and fantasy football players who were relying on the NFC West team's running backs are probably all ...

The 49ers authorized a two-year, $38MM extension this offseason, with the deal coming with $24MM at signing. McCaffrey, 28, played the lead role in powering San Francisco’s offense last season. With ...

San Francisco 49ers quarterback Brock Purdy is expected to play Sunday night against the Buffalo Bills, according to ESPN's ...

That's clearly a big boost to San Francisco's air attack ... However, both the 49ers and Bills could face a challenge on offense -- and specifically in the passing game -- Sunday with the forecast ...

NFL analyst reports that the 49ers and Raiders are the top suitors for free agent quarterback Daniel Jones following his ...

As injuries once again define a 49ers NFC title defense, the team still has some silver linings in the form of defenders ...

The 49ers got outplayed in every way by the Packers on Sunday and George Kittle is pointing the finger at the entire team.

The trade likely will go down as one of the worst in team history. 49ers General Manager John Lynch admitted his team got more for Lance than expected. San Francisco used the 124th overall pick on ...

As the Chicago Bears look to face the San Francisco 49ers next week, rumors are swirling as to who will be among the ...

The other positive news for the San Francisco 49ers is that their run defense has been pretty good so far. They rank in the top ten in both rushing yards allowed per game and yards per carry allowed.

A starter in seven regular-season games and all three 49ers playoff contests, Feliciano suffered the knee injury during ...