San Francisco 49ers vs Buffalo Bills showdown with essential stats, lineup predictions and injury updates you won’t want to ...

The San Francisco 49ers are mourning the loss of a three-time Super Bowl champion. One of the best defensive linemen in San ...

Those 11 straight division championships clinched an NFL record. Patrick Mahomes and the Kansas City Chiefs are looking to ...

49ers Promote CB Nick McCloud and Other Roster Moves Ahead of #SFvsBUF The San Francisco 49ers promoted CB Nick McCloud to the active roster from the team's practice squad and activated LB Jalen ...

The San Francisco 49ers announced they have signed OL Sebastian Gutierrez to the team's practice squad. In order to make room on the practice squad, the team released OL Cameron Erving.

San Francisco 49ers three-time Super Bowl champion has suddenly passed away at 80, the team announced on Thursday.

That's clearly a big boost to San Francisco's air attack ... However, both the 49ers and Bills could face a challenge on offense -- and specifically in the passing game -- Sunday with the forecast ...

Discover the greatest RBs in San Francisco 49ers history: from Super Bowl heroes to game-changing performers, find out who ...

The nightcap of Sunday's action will be in northern New York with the Buffalo Bills (9-2) hosting the San Francisco 49ers (5-6). San Francisco has been up and down all season, but the Super Bowl ...

The San Francisco 49ers and Buffalo Bills play Sunday, Dec. 1, at Buffalo's Highmark Stadium in a game on the NFL Week 13 schedule. Which team will win the Sunday Night Football game? Check out ...

The San Francisco 49ers had a chance to move to 6-4 on the season last week at home against the Seattle Seahawks. Kyle Shanahan’s squad held a 17-13 lead late in the fourth quarter despite ...

Kyle Shanahan and the San Francisco 49ers are now under .500 after Sunday's loss to the Packers. (AP ... [+] Photo/Matt Ludtke) Brock Purdy made the trip to Green Bay as the San Francisco 49ers ...