Renin acts on its substrate, angiotensinogen ... In some forms of hypertension, a marked derangement of the renin system can be identified. At one extreme, rare renin-secreting tumors of the ...

In a complicated system of feedback loops, the kidneys are able to detect a change in blood pressure, leading to a release of the enzyme renin. Renin converts the precursor angiotensinogen to ...

The renin-angiotensin system has a major role in blood pressure regulation and cardiovascular function. ACE, a key element of this system, converts the inactive decapeptide angiotensin I into the ...