The immune response plays an important role in disease; however, immune-mediated mechanisms of pathogenesis and regulation are not understood. In this study, we determined that a pathogenic Th17 ...

Transforming growth factor β (TGFβ) is a critical differentiation factor for the generation of regulatory T (T-reg) cells, whereas the combination of interleukin 6 (IL6) and TGFβ induces the ...

Lewis Zhichang Shi, M.D., Ph.D., with coauthors, recently published the research, “HIF1α -regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells,” in the ...

We thank Tricia Niles for help with flow cytometry, Damien Chopy for help with early experiments, and Drs. Alan Scott and Jay Bream for helpful advice. This work was supported by Grants F31 NS076223 ...

Objective To determine the microRNA (miR) signature in ankylosing spondylitis (AS) T helper (Th)17 cells. Methods Interleukin (IL)-17A-producing CD4+ T cells from patients with AS and healthy controls ...

It has been a year ago since bacteria from war-wounded at hospitals in Ukraine were analyzed. The study showed that some of the bacteria types had total resistance to antibiotics. Now, the same ...

Th17 cells have recently been suggested to play a pathogenic role in experimental autoimmune encephalomyelitis and collagen-induced arthritis (a model of rheumatoid arthritis). However ...